1-Methyl-1H-pyrazole-5-sulfonyl chloride → HCID 56602713, compound

HRID 1260490Notes

Reaction equation

HRID 1260490 reaction equation
[OH:1][CH:2]1[CH2:23][NH:22][CH2:21][CH2:20][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2.[CH3:24][N:25]1[C:29]([S:30](Cl)(=[O:32])=[O:31])=[CH:28][CH:27]=[N:26]1>>[OH:1][CH:2]1[CH2:23][N:22]([S:30]([C:29]2[N:25]([CH3:24])[N:26]=[CH:27][CH:28]=2)(=[O:32])=[O:31])[CH2:21][CH2:20][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2

Participants

3

Reactant 2

HCID 224726211-Methyl-1H-pyrazole-5-sulfonyl chlorideHCID 58056621HCID 58056621, compound

Product 1

HCID 56602713HCID 56602713, compound

Procedure

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (described in example 7 step B) and 2-methyl-2H-pyrazole-3-sulfonyl chloride. Light yellow solid. MS (ESI): 473.2 (MH+)

Sources & evidence

ORD record
ord-ff6189e725d44692bf7c271aa86e3bb5
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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