HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethylpropane-1-sulfonyl chloride → (5RS,6RS)-8-(2,2-Dimethyl-propane-1-sulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethylpropane-1-sulfonyl chloride | HCID 12574632 | — |
| Reactant | HCID 58056621 | HCID 58056621 | — |
| Product | (5RS,6RS)-8-(2,2-Dimethyl-propane-1-sulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 56602714 | — |
Reaction Steps
The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (described in example 7 step B) and 2,2-dimethyl-propane-1-sulfonyl chloride. Light yellow solid. MS (ESI): 463.2 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470843B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-7fce3c4fc6614ad5800aeb3c24ea7062 |
| Source note | uspto-grants-2013_06 |