1-Benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester → (5 SR,6RS)-8-benzyl-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Participants

Reaction Steps

The title compound was prepared in analogy to example 1 step C from a mixture of (3RS,4SR)-1-benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester and (rac)-4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine. Light yellow solid. MS (ESI): 449.2 (MH+)

Provenance & Evidence