2-Chlorobenzenesulfonyl chloride → (5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 1260494Notes

Reaction equation

HRID 1260494 reaction equation
[OH:1][CH:2]1[CH2:25][NH:24][CH2:23][CH2:22][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2.[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[S:33](Cl)(=[O:35])=[O:34]>>[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[S:33]([N:24]1[CH2:23][CH2:22][C:3]2([C:7](=[O:8])[N:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH:16]([CH3:21])[C:17]([F:20])([F:18])[F:19])=[CH:11][CH:10]=3)[CH2:5][CH2:4]2)[CH:2]([OH:1])[CH2:25]1)(=[O:35])=[O:34]

Participants

3

Reactant 2

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 58056627HCID 58056627, compound

Product 1

HCID 56602715(5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one and 2-chloro-benzenesulfonyl chloride. Light yellow solid. MS (ESI): 533.1 (MH+)

Sources & evidence

ORD record
ord-69447d16a96e4cb9a0d671499edd0b0c
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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