1-Methyl-1H-pyrazole-5-sulfonyl chloride → HCID 56602716, compound

HRID 1260495Notes

Reaction equation

HRID 1260495 reaction equation
[OH:1][CH:2]1[CH2:25][NH:24][CH2:23][CH2:22][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2.[CH3:26][N:27]1[C:31]([S:32](Cl)(=[O:34])=[O:33])=[CH:30][CH:29]=[N:28]1>>[OH:1][CH:2]1[CH2:25][N:24]([S:32]([C:31]2[N:27]([CH3:26])[N:28]=[CH:29][CH:30]=2)(=[O:34])=[O:33])[CH2:23][CH2:22][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH:16]([CH3:21])[C:17]([F:20])([F:18])[F:19])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2

Participants

3

Reactant 2

HCID 224726211-Methyl-1H-pyrazole-5-sulfonyl chlorideHCID 58056627HCID 58056627, compound

Product 1

HCID 56602716HCID 56602716, compound

Procedure

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (described in example 10 step B) and 2-methyl-2H-pyrazole-3-sulfonyl chloride. Light yellow solid. MS (ESI): 503.1 (MH+)

Sources & evidence

ORD record
ord-1f675866d37f4fc1a4642744612f39f8
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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