Bromocyclopentane → HCID 178474768, compound

HRID 1260509Notes

Reaction equation

HRID 1260509 reaction equation
[CH2:1]([O:8][C:9]1[CH:28]=[CH:27][C:12]([O:13][C@@H:14]2[CH2:19][O:18][C@@H:17]([CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:16][CH2:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=CC=1.C1(Br)CCCC1>>[CH:1]1([O:8][C:9]2[CH:28]=[CH:27][C:12]([O:13][C@@H:14]3[CH2:19][O:18][C@@H:17]([CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:16][CH2:15]3)=[CH:11][CH:10]=2)[CH2:5][CH2:6][CH2:7][CH2:2]1

Participants

3

Reactant 2

HCID 8728BromocyclopentaneHCID 178474771HCID 178474771, compound

Product 1

HCID 178474768HCID 178474768, compound

Procedure

trans-N-{3-[5-(4-Benzyloxyphenoxy)-[1,3]dioxan-2-yl]propyl}acetamide (24 mg, 0.062 mmol) was hydrogenated and reacted with cyclopentyl bromide in analogy to example 5. Yield: 6 mg (34%) M+H+: 364.21.

Sources & evidence

ORD record
ord-c2813e89af4748e3981deb8b20664fe8
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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