3-(Benzyloxy)-6-chloropyridazine → N-{3-[4-(6-Benzyloxypyridazin-3-yloxy)phenyl]-1-methylpropyl}acetamide

HRID 1260517Notes

Reaction equation

HRID 1260517 reaction equation
[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12](Cl)=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:19][CH:18]=1>>[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:21][CH:22]=2)=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 225069573-(Benzyloxy)-6-chloropyridazineHCID 59956161N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamide

Product 1

HCID 44608625N-{3-[4-(6-Benzyloxypyridazin-3-yloxy)phenyl]-1-methylpropyl}acetamide

Procedure

3-Benzyloxy-6-chloropyridazine (411 mg, 1.86 mmol) was reacted with N-[3-(4-hydroxyphenyl)-1-methylpropyl]acetamide in analogy to example 1b.

Sources & evidence

ORD record
ord-ebabbbc0503748b3bad0cb9a7c50e8eb
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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