N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamide → HCID 67302547, compound

HRID 1260523Notes

Reaction equation

HRID 1260523 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](OC2C=NC(Cl)=CC=2)=[N:6][CH:7]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:21][CH:22]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 59956161N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamideHCID 86656065HCID 86656065, compound

Product 1

HCID 67302547HCID 67302547, compound

Procedure

5-Bromo-2-(6-chloropyridin-3-yloxy)pyrimidine (500 mg, 1.745 mmol) and N-[3-(4-hydroxyphenyl)-1-methylpropyl]acetamide (362 mg, 1.745 mmol) were reacted in analogy to example 2c. Yield: 509 mg (80%), M+H+: 364.03.

Sources & evidence

ORD record
ord-204030eb9b4541ed93c8c8ce64556175
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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