Isopropyl iodide → HCID 58369097, compound

HRID 1260525Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.I[CH:24]([CH3:26])[CH3:25]>>[CH:24]([O:1][C:2]1[CH:3]=[N:4][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:13][CH:14]=2)=[N:6][CH:7]=1)([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 67071805HCID 67071805, compound

Product 1

HCID 58369097HCID 58369097, compound

Procedure

N-{3-[4-(5-Hydroxypyrimidin-2-yloxy)phenyl]-1-methylpropyl}acetamide (125 mg, 0.41 mg) was reacted with 2-iodopropane in analogy to example 36f. Yield: 9 mg (6%), M+H+: 344.14.

Sources & evidence

ORD record: ord-29a1ac1bbd2847b6b0b05e5ce5fc917f
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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