Acetic Anhydride → HCID 58369091, compound

HRID 1260529Notes

Reaction equation

F[C:2](F)(F)[C:3](O)=[O:4].[CH:8]([O:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][C:19]2[CH:29]=[CH:28][C:22]([O:23][CH2:24][CH:25]([NH2:27])[CH3:26])=[CH:21][CH:20]=2)=[N:16][CH:17]=1)([CH3:10])[CH3:9].C(OC(=O)C)(=O)C>>[CH:8]([O:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][C:19]2[CH:29]=[CH:28][C:22]([O:23][CH2:24][CH:25]([NH:27][C:3](=[O:4])[CH3:2])[CH3:26])=[CH:21][CH:20]=2)=[N:16][CH:17]=1)([CH3:9])[CH3:10]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 67071818HCID 67071818, compound

Product 1

HCID 58369091HCID 58369091, compound

Procedure

2-[4-(5-Isopropoxypyridin-2-yloxy)phenoxy]-1-methylethylamine trifluoroacetate (624 mg, 1.5 mmol) was reacted with acetic anhydride in analogy to example 2a. Yield: 251 mg (49%), M+H+: 345.12.

Sources & evidence

ORD record: ord-d65e4353277d4fd48434db0ce738479b
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

Loading…