Isopropyl iodide → HCID 49855598, compound

HRID 1260533Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.I[CH:24]([CH3:26])[CH3:25]>>[CH:24]([O:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[N:6][CH:7]=1)([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 67071581HCID 67071581, compound

Product 1

HCID 49855598HCID 49855598, compound

Procedure

N—{(S)-3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide (153 mg, 0.51 mmol) was reacted with 2-iodopropane in analogy to example 1a. Yield: 61 mg (35%), M+H+: 343.15.

Sources & evidence

ORD record: ord-eb24e7dcf5b846bf8200de5329a25feb
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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