Isopropyl iodide → HCID 67071857, compound

HRID 1260535Notes

Reaction equation

[OH:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.I[CH:24]([CH3:26])[CH3:25]>>[CH:24]([N:7]1[C:2](=[O:1])[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[CH:6]1)([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 178474734HCID 178474734, compound

Product 1

HCID 67071857HCID 67071857, compound

Procedure

N-{3-[4-(6-Hydroxypyridin-3-yloxy)phenyl]-1-methylpropyl}acetamide (168 mg, 1.49 mmol) was reacted with 2-iodopropane in analogy to example 36f. Yield: 26 mg (15%), M+H+: 343.20. N-{3-[4-(1-Isopropyl-6-oxo-1,6-dihydropyridin-3-yloxy)phenyl]1-methylpropyl}acetamide was obtained as by-product.

Sources & evidence

ORD record: ord-e46cc3dc164e45e1ad31dd35c32ffa8e
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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