Acetic Anhydride → HCID 67071634, compound

HRID 1260538Notes

Reaction equation

HRID 1260538 reaction equation
[CH2:1]([O:8][C:9]1[N:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[C:23][CH:24]([NH2:26])[CH3:25])=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27](OC(=O)C)(=[O:29])[CH3:28]>>[CH2:1]([O:8][C:9]1[N:14]=[CH:13][C:12]([O:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]#[C:23][CH:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])=[CH:20][CH:21]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 67071633HCID 67071633, compound

Product 1

HCID 67071634HCID 67071634, compound

Procedure

3-[4-(6-Benzyloxypyridin-3-yloxy)phenyl]-1-methylprop-2-ynylamine (705 mg, 6.97 mmol) was reacted with acetic anhydride in analogy to example 2a. Yield: 370 mg (41%), M+H+: 387.42:

Sources & evidence

ORD record
ord-b64ce7be99f84476b960d64c10f79490
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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