HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Benzyl {(S)-2-[6-(4-benzyloxyphenoxy)pyridin-3-yloxy]-1-methylethyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-(4-Benzyloxyphenoxy)pyridin-3-ol | HCID 67071547 | — |
| Reactant | (S)-Benzyl (1-bromopropan-2-yl)carbamate | HCID 71301833 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl {(S)-2-[6-(4-benzyloxyphenoxy)pyridin-3-yloxy]-1-methylethyl}carbamate | HCID 86761884 | — |
Reaction Steps
6-(4-Benzyloxyphenoxy)pyridin-3-ol (250 mg, 0.85 mmol) and benzyl ((S)-2-bromo-1-methylethyl)carbamate (232 mg, 0.85 mmol) were reacted with sodium hydride in DMF in analogy to example 1a. Yield: 118 mg (29%), M+H+: 485.11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470841B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-39a456377ac14238b7ca8c9e5785e9a0 |
| Source note | uspto-grants-2013_06 |