HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl {(S)-2-[6-(4-benzyloxyphenoxy)pyridin-3-yloxy]-1-methylethyl}carbamate → 4-[5((S)-2-Aminopropoxy)pyridin-2-yloxy]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl {(S)-2-[6-(4-benzyloxyphenoxy)pyridin-3-yloxy]-1-methylethyl}carbamate | HCID 86761884 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[5((S)-2-Aminopropoxy)pyridin-2-yloxy]phenol | HCID 67071800 | — |
Reaction Steps
Benzyl {(S)-2-[6-(4-benzyloxyphenoxy)pyridin-3-yloxy]-1-methylethyl}carbamate (118 mg, 0.24 mmol) were hydrogenated in ethanol over 5% of palladium on carbon at 5 bar hydrogen pressure. The catalyst was filtered off and the filtrate was concentrated: Yield: 43 mg (68%), M+H+: 261.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470841B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-5b1d832e9f1942d68545aa0e7bdcfe6b |
| Source note | uspto-grants-2013_06 |