Acetic Anhydride → N-{(S)-2-[6-(4-Hydroxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide

HRID 1260546Notes

Reaction equation

HRID 1260546 reaction equation
[NH2:1][C@@H:2]([CH3:19])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[N:9][CH:10]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[OH:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][C:8]2[N:9]=[CH:10][C:5]([O:4][CH2:3][C@@H:2]([NH:1][C:20](=[O:22])[CH3:21])[CH3:19])=[CH:6][CH:7]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 670718004-[5((S)-2-Aminopropoxy)pyridin-2-yloxy]phenol

Product 1

HCID 67071771N-{(S)-2-[6-(4-Hydroxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide

Procedure

4-[5((S)-2-Aminopropoxy)pyridin-2-yloxy]phenol (42 mg, 0.16 mmol) were reacted with acetic anhydride in analogy to example 2a. Yield: 33 mg (68%), M+H+: 303.05.

Sources & evidence

ORD record
ord-650decec22a14f4f9899aa0ff1dc82f6
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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