Triethylsilane → HCID 67071808, compound

Participants

Reaction Steps

(4-Hydroxyphenyl)-(6-isopropoxypyridin-3-yl)methanone (300 mg, 1.17 mmol) was dissolved in 15 ml of THF. Following addition of triethylsilane (678 mg, 5.83 mmol) the mixture was stirred at room temperature for 2 days. Following addition of 116 mg of triethylsilane the mixture was stirred at 60° C. for 8 h, concentrated and admixed with ethyl acetate and water, and the organic phase was separated off, concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 52 mg (18%), M+H+: 244.14.

Provenance & Evidence