Water → HCID 49855401, compound

Participants

Reaction Steps

3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine trifluoroacetate (115 mg, 0.28 mmol) and triethylamine (0.117 ml, 0.83 mmol) were dissolved in 5 ml of dichloromethane. Cyclopropanecarbonyl chloride (0.043 ml, 0.46 mmol) was added at 0° C. and the reaction mixture was stirred for 3 hours during which it warmed to room temperature. Following addition of water, the organic phase was separated off, concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 63 mg (62%), M+H+: 369.25.

Provenance & Evidence