Methyl chloroformate → HCID 49855400, compound

HRID 1260553Notes

Reaction equation

FC(F)(F)C(O)=O.[CH:8]([O:11][C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]([NH2:29])[CH3:28])=[CH:21][CH:20]=2)=[CH:14][CH:13]=1)([CH3:10])[CH3:9].Cl[C:31]([O:33][CH3:34])=[O:32]>>[CH:8]([O:11][C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][CH:27]([NH:29][C:31](=[O:32])[O:33][CH3:34])[CH3:28])=[CH:23][CH:24]=2)=[CH:14][CH:13]=1)([CH3:10])[CH3:9]

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 67071742HCID 67071742, compound

Product 1

HCID 49855400HCID 49855400, compound

Procedure

3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine trifluoroacetate (115 mg, 0.28 mmol) was reacted with methyl chloroformate in analogy to example 44. Yield: 48 mg (48%), M+H+: 359.13.

Sources & evidence

ORD record: ord-f065763bed5c40038690ec2eab2dc163
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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