Cesium carbonate → HCID 49858289, compound

Participants

Reaction Steps

2-Bromo-5-isopropoxypyrazine (100 mg, 0.46 mmol), N-[3-(4-hydroxyphenyl)-1-methylpropyl]acetamide (143 mg, 0.69 mmol), cesium carbonate (300 mg, 0.92 mmol), copper iodide (8.77 mg, 0.046 mmol) and N,N-dimethylglycine hydrochloride (19.3 mg, 0.138 mmol) were stirred in 2 ml of dioxane at 100° C. under argon for 7 h. The batch was filtered, the filtrate was concentrated and admixed with ethyl acetate and water, and the organic phase was separated off, concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 88 mg (56%), M+H+: 344.16.

Provenance & Evidence