Acetic Anhydride → HCID 67071689, compound

HRID 1260563Notes

Reaction equation

[CH:1]([O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C@@H:20]([NH2:24])[CH:21]([CH3:23])[CH3:22])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[C:25](OC(=O)C)(=[O:27])[CH3:26]>>[CH:1]([O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C@@H:20]([NH:24][C:25](=[O:27])[CH3:26])[CH:21]([CH3:23])[CH3:22])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 67071612HCID 67071612, compound

Product 1

HCID 67071689HCID 67071689, compound

Procedure

(R)-1-{2-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]ethyl}-2-methylpropylamine (48.7 mg, 0.148 mmol) was reacted with acetic anhydride in analogy to example 2a. Yield: 42 mg (77%), M+H+: 371.3.

Sources & evidence

ORD record: ord-ba8251526933499b8c3e3d437c3e79e5
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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