Trifluoroacetic acid → HCID 67071750, compound

Participants

Reaction Steps

tert-Butyl {2-[4-(4-benzyloxyphenoxy)phenoxy]-1-methylethyl}carbamate (837 mg, 1.86 mmol) was treated with 90 percent strength trifluoroacetic acid. The trifluoroacetic acid was distilled off and the aqueous phase was freeze dried. Chromatography was performed on a chiral column (ChiralpakAD-H/91, 250 4.6 mm, eluent: heptane/ethanol=3:1+0.1% DEA) for enantiomer separation (S)-2-[4-(4-Benzyloxyphenoxy)phenoxy]-1-methylethylamine (RF: 11.667 min.), Yield: 230 mg (35%), M+H+: 350.19, (R)-2-[4-(4-benzyloxyphenoxy)phenoxy]-1-methylethylamine (RF: 13.122 min.), Yield: 226 mg (35%), M+H+: 350.19.

Provenance & Evidence