Acetic Anhydride → HCID 67071722, compound

HRID 1260570Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([O:13][C:14]2[CH:24]=[CH:23][C:17]([O:18][CH2:19][C@@H:20]([NH2:22])[CH3:21])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27](OC(=O)C)(=[O:29])[CH3:28]>>[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([O:13][C:14]2[CH:24]=[CH:23][C:17]([O:18][CH2:19][C@@H:20]([NH:22][C:27](=[O:29])[CH3:28])[CH3:21])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 67071750HCID 67071750, compound

Product 1

HCID 67071722HCID 67071722, compound

Procedure

(S)-2-[4-(4-Benzyloxyphenoxy)phenoxy]-1-methylethylamine (195 mg, 0.56 mmol) was reacted with acetic anhydride in analogy to example 2a. Yield: 218 mg (100%), M+H+: 392.18.

Sources & evidence

ORD record: ord-9c69fe909b7744de8a806875625e1e12
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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