Isopropyl iodide → HCID 25152672, compound

HRID 1260571Notes

Reaction equation

[OH:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:18])[CH3:17])[CH3:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.I[CH:24]([CH3:26])[CH3:25]>>[CH:24]([O:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:18])[CH3:17])[CH3:14])=[CH:9][CH:8]=2)=[CH:21][CH:22]=1)([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 67071721HCID 67071721, compound

Product 1

HCID 25152672HCID 25152672, compound

Procedure

N—{(S)-2-[4-(4-Hydroxyphenoxy)phenoxy]-1-methylethyl}acetamide (139 mg, 0.46 mmol) was reacted with 2-iodopropane in analogy to example 10b. Yield: 51 mg (32%), M+H+: 344.23.

Sources & evidence

ORD record: ord-011ffd90303a49bf9013bf14e3b6dfef
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470841B2

Reaction notes

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