反应详情

A solution of 18.0 g (84.4 mmol) of 2,6-dichloronicotinic acid in 180 ml of a solution of ethylamine at 70% in water is stirred at ambient temperature for 72 hours. The excess amine is then evaporated off under reduced pressure, and an aqueous solution of acetic acid at 10% is then added until the product precipitates. The beige solid is spin-filter-dried, rinsed with cold water and dried in an oven. 10.5 g of the expected product are obtained. Melting point: 158-160° C. Yield=62%.

1. customThe excess amine is then evaporated off under reduced pressure
2. additionan aqueous solution of acetic acid at 10% is then added until the product
3. customprecipitates
4. customThe beige solid is spin-filter-dried
5. washrinsed with cold water
6. customdried in an oven