反应详情

温度

100 °C

4 g of 2,6-dichloronicotinic acid (20.83 mmol, Aldrich) and 10.74 ml of 2-(aminomethyl)pyridine (104.17 mmol) are placed in an 80 ml sealed tube containing 40 ml of tert-butanol. The mixture is heated at 100° C. overnight and evaporated to dryness. The residue is taken up in water and the mixture is acidified by pouring in an aqueous solution of acetic acid at 10%. The precipitate is isolated by filtration and, after drying in an oven under a reduced vacuum, 4.35 g of expected product are obtained in the form of a yellow powder (yield=79%).

1. customsealed tube
2. customevaporated to dryness
3. additionby pouring in an aqueous solution of acetic acid at 10%
4. customThe precipitate is isolated by filtration
5. dry with materialafter drying in an oven under a reduced vacuum, 4.35 g of expected product