Triethylamine → HCID 42602999, compound

Participants

Reaction Conditions

Reaction Steps

Previous amine (0.2 g 1.08 mmol) was dissolved in DMF (3 ml) and cooled to 0° C. Then HOBT (0.0432 g 0.318 mmol), EDCI (0.303 g 1.59 mmol) were added followed by triethylamine (0.44 ml) and 2-fluorobenzoic acid (0.178 g 1.27 mmol). The mixture was stirred at RT overnight, quenched with quenched with 20 ml of 10% sodium bicarbonate solution and extracted with ethyl acetate. Ethyl acetate was concentrated and pure product obtained by column chromatography as off white solid (0.050 g).

Provenance & Evidence