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HRID1260605

反应详情

EQUATION

反应方程式

HRID 1260605 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)C(C)c1c(C)n(S(=O)(=O)c2ccc(Cl)c(Cl)c2)c2ncccc12
HCID67219256

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(C(C)C(=O)O)c2cccnc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1
HCID11697284

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CO
溶剂HCID21899815

未命名化合物

PROCEDURE

实验过程

1M Aqueous NaOH (0.25 mL) is added to a stirring solution of 2-[1-(3,4-dichloro-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-propionic acid methyl ester (17 mg, 0.04 mmol) in 1:1 THF/MeOH (1 mL). After 4 hours, the reaction is evaporated and the residue dissolved in water. The aqueous solution is acidified to pH 1, and resulting solid is collected by filtration. The crude product is purified by flash chromatography (10:1 EtOAc/MeOH), followed by trituration with iso-hexane, to afford 2-[1-(3,4-dichloro-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-propionic acid; MH+=413.

WORKUP

后处理

  1. customthe reaction is evaporated
  2. dissolutionthe residue dissolved in water
  3. customresulting solid
  4. filtrationis collected by filtration
  5. customThe crude product is purified by flash chromatography (10:1 EtOAc/MeOH)