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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1260637Generated: November 1, 2026

4-Fluoro-3-(trifluoromethyl)benzaldehyde → 1-Bromomethyl-4-ethanesulfonyl-2-trifluoromethyl-benzene

https://huagongshe.com/reaction/1260637

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(trifluoromethyl)benzaldehydeHCID 522269—
Reactant1-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzeneHCID 2761083—
ReactantSodium EthanesulfinateHCID 22986214—
Product1-Bromomethyl-4-ethanesulfonyl-2-trifluoromethyl-benzeneHCID 67219835—

Reaction Steps

The titled compound is prepared analogously to 1-bromomethyl-2-chloro-4-methanesulfonyl-benzene by replacing 2-chloro-4-fluorobenzaldehyde (step 90a) with 4-fluoro-3-trifluoromethylbenzaldehyde and by replacing sodium methanesulfinate with sodium ethanesulfinate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08470848B2
Source datasetuspto-grants-2013_06
ORD IDord-7757de08df804fce9243b0f9320eb06c
Source noteuspto-grants-2013_06