Acetic Acid → HCID 178474977, compound

HRID 1260713Notes

Reaction equation

HRID 1260713 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH:21]4[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1.[C:28](O)(=[O:30])[CH3:29]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:28](=[O:30])[CH3:29])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 66653411HCID 66653411, compound2×

Product 1

HCID 178474977HCID 178474977, compound

Procedure

The title compound, white solid (30 mg, 41%), MS (ISP) m/z=371.3 [(M+H)+], mp 157° C., was prepared in accordance with the general method of example 6 from 4-[2-(4-furo[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate C) (88 mg, 0.2 mmol) and acetic acid.

Sources & evidence

ORD record
ord-dd4e21997d8247388dc83c687873def1
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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