2-Methanesulfonylacetic acid → HCID 178504903, compound

HRID 1260719Notes

Reaction equation

HRID 1260719 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH:21]4[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1.[CH3:28][S:29]([CH2:32][C:33](O)=[O:34])(=[O:31])=[O:30]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:33](=[O:34])[CH2:32][S:29]([CH3:28])(=[O:31])=[O:30])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1

Participants

3

Reactant 2

HCID 37328412-Methanesulfonylacetic acidHCID 66653411HCID 66653411, compound2×

Product 1

HCID 178504903HCID 178504903, compound

Procedure

The title compound, white solid (72 mg, 80%), MS (ISP) m/z=449.3 [(M+H)+], mp 182° C., was prepared in accordance with the general method of example 6 from 4-[2-(4-furo[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate C) (88 mg, 0.2 mmol) and 2-methanesulfonyl-acetic acid.

Sources & evidence

ORD record
ord-b03ffe7b18dd4a2cb6fb762de6d9a3d4
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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