HCID 55301231, compound → HCID 178520766, compound

HRID 1260736Notes

Reaction equation

HRID 1260736 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][O:31][CH2:30][C@H:29]1[CH2:34][C:35](O)=[O:36]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:35](=[O:36])[CH2:34][C@@H:29]5[CH2:30][O:31][CH2:32][CH2:33][O:28]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 55301231HCID 55301231, compoundHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178520766HCID 178520766, compound

Procedure

The title compound, white solid (52 mg, 71%), MS (ISP) m/z=459.5 [(M+H)+], mp 181° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (70.4 mg, 0.16 mmol) (R)-2-(1,4-dioxan-2-yl)acetic acid.

Sources & evidence

ORD record
ord-4bb1e8dd38ad44dd805970e98cad2f14
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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