Butanoic acid, 4-(dimethylamino)-4-oxo- → HCID 178484545, compound

HRID 1260742Notes

Reaction equation

HRID 1260742 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][N:29]([CH3:37])[C:30](=[O:36])[CH2:31][CH2:32][C:33](O)=[O:34]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:33](=[O:34])[CH2:32][CH2:31][C:30]([N:29]([CH3:37])[CH3:28])=[O:36])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 75717Butanoic acid, 4-(dimethylamino)-4-oxo-HCID 178478590HCID 178478590, compound2×

Product 1

HCID 178484545HCID 178484545, compound

Procedure

The title compound, white solid (103 mg, 90%), MS (ISP) m/z=458.6 [(M+H)+], mp 177.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4-(dimethylamino)-4-oxobutanoic acid.

Sources & evidence

ORD record
ord-0895dbe2fd3a4d858ce89fba0273a74a
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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