4-(Piperidin-1-yl)benzoic acid → HCID 178523731, compound

HRID 1260757Notes

Reaction equation

HRID 1260757 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[N:28]1([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:38](=[O:39])[C:37]5[CH:41]=[CH:42][C:34]([N:28]6[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]6)=[CH:35][CH:36]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 7645994-(Piperidin-1-yl)benzoic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523731HCID 178523731, compound

Procedure

The title compound, white solid (99 mg, 77%), MS (ISP) m/z=518.5 [(M+H)+], mp 182.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4-piperidin-1-yl-benzoic acid.

Sources & evidence

ORD record
ord-5eeee2ce81e44830aa431fbcd6c757d7
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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