3,3,3-Trifluoro-2-hydroxypropanoic acid → HCID 178523743, compound

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Reaction Steps

The title compound, yellow solid (110 mg, 96%), MS (ISP) m/z=457.4 [(M+H)+], mp 185° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and (RS)-3,3,3-trifluoro-2-hydroxy-propionic acid.

Provenance & Evidence