4-(1H-pyrazol-1-yl)benzoic acid → HCID 178523732, compound

HRID 1260765Notes

Reaction equation

HRID 1260765 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[N:28]1([C:33]2[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=2)[CH:32]=[CH:31][CH:30]=[N:29]1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:37](=[O:38])[C:36]5[CH:35]=[CH:34][C:33]([N:28]6[CH:32]=[CH:31][CH:30]=[N:29]6)=[CH:41][CH:40]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 7365274-(1H-pyrazol-1-yl)benzoic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523732HCID 178523732, compound

Procedure

The title compound, white solid (107 mg, 86%), MS (ISP) m/z=501.4 [(M+H)+], mp 225.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4-pyrazol-1-yl-benzoic acid.

Sources & evidence

ORD record
ord-28958c807d7f49bb80be2e43f056e1b1
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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