4-tert-Butoxybenzoic Acid → HCID 178450181, compound

HRID 1260776Notes

Reaction equation

HRID 1260776 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[C:28]([O:32][C:33]1[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]1[CH:34]=[CH:35][C:36]([C:37]([NH:27][C@H:24]2[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]3[CH2:17][CH2:18][N:13]([C:9]4[N:10]=[CH:11][CH:12]=[C:7]5[CH2:6][CH2:5][O:4][C:8]=45)[CH2:14][CH2:15]3)[CH2:22][CH2:23]2)=[O:38])=[CH:40][CH:41]=1)([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 5353024-tert-Butoxybenzoic AcidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178450181HCID 178450181, compound

Procedure

The title compound, white solid (113 mg, 89%), MS (ISP) m/z=507.4 [(M+H)+], mp 168.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4-tert-butoxy-benzoic acid.

Sources & evidence

ORD record
ord-5bfb2d59889d4c5eb1aad12817b47dee
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…