4,4,4-Trifluorobutanoic acid → HCID 178520634, compound

HRID 1260784Notes

Reaction equation

HRID 1260784 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[F:28][C:29]([F:36])([F:35])[CH2:30][CH2:31][C:32](O)=[O:33]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:32](=[O:33])[CH2:31][CH2:30][C:29]([F:36])([F:35])[F:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 27770854,4,4-Trifluorobutanoic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178520634HCID 178520634, compound

Procedure

The title compound, white solid (106 mg, 93%), MS (ISP) m/z=455.3 [(M+H)+], mp 204.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4,4,4-trifluoro-butanoic acid.

Sources & evidence

ORD record
ord-860c7f92b0124b2c8a4e5608516fba7f
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…