HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluorocyclopropane-1-carboxylic acid → HCID 178523719, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluorocyclopropane-1-carboxylic acid | HCID 2782823 | — |
| Reactant | HCID 178478590 | HCID 178478590 | — |
| Product | HCID 178523719 | HCID 178523719 | — |
Reaction Steps
The title compound, white solid (99 mg, 91%), MS (ISP) m/z=435.3 [(M+H)+], mp 227° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 2,2-difluoro-cyclopropane-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470828B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-a4fff127206943688a376b4d1a5043f5 |
| Source note | uspto-grants-2013_06 |