HCID 178478590, compound → HCID 178496554, compound

HRID 1260791Notes

Reaction equation

HRID 1260791 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][O:29][C@H:30]1[CH2:35][CH2:34][C@H:33]([CH2:36][C:37](O)=[O:38])[CH2:32][CH2:31]1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:37](=[O:38])[CH2:36][C@H:33]5[CH2:34][CH2:35][C@H:30]([O:29][CH3:28])[CH2:31][CH2:32]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 178478590HCID 178478590, compound2×HCID 178496559HCID 178496559, compound

Product 1

HCID 178496554HCID 178496554, compound

Procedure

The title compound, white solid (106 mg, 88%), MS (ISP) m/z=485.5 [(M+H)+], mp 188.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and trans-2-(4-methoxy-cyclohexyl)-acetic acid.

Sources & evidence

ORD record
ord-6a4d7002af9c4a6faeb35efe5d0b2b80
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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