2-(HYDROXYCYCLOBUTYL)ACETIC ACID → HCID 178520406, compound

HRID 1260800Notes

Reaction equation

HRID 1260800 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[OH:28][C:29]1([CH2:33][C:34](O)=[O:35])[CH2:32][CH2:31][CH2:30]1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34](=[O:35])[CH2:33][C:29]5([OH:28])[CH2:32][CH2:31][CH2:30]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 574682122-(HYDROXYCYCLOBUTYL)ACETIC ACIDHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178520406HCID 178520406, compound

Procedure

The title compound, white solid (62 mg, 56%), MS (ISP) m/z=443.5 [(M+H)+], mp 155° C., was prepared in accordance with the general method of example 5 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 2-(1-hydroxy-cyclobutyl)-acetic acid.

Sources & evidence

ORD record
ord-6b1c14d1d2cb42639f2bc19830645fdd
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…