2-Aminopyridine-3-carboxamide → 1-(2,5-Dichlorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-aminonicotinamide (0.2 g) in N,N-dimethylformamide (5 ml) was added 2,5-dichlorobenzylbromide (0.39 g) (Table 2, bromide 122), and the mixture was stirred at 80° C. for 14 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (0.21 g).

Provenance & Evidence