3,5-Dichlorobenzyl chloride → 1-(3,5-Dichlorobenzyl)-2imino-1,2-dihydropyridine-3-carboxamide hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-aminonicotinamide (0.18 g) in N,N-dimethylformamide (3 ml) was added 3,5-dichlorobenzyl chloride (0.31 g), and the mixture was stirred at 80° C. for 14 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (0.10 g).

Provenance & Evidence