Benzonitrile, 3-(bromomethyl)- → HCID 68661583, compound

Participants

Reaction Conditions

Reaction Steps

(Step 2) To a solution of 2-amino-5-chloronicotinamide (0.14 g) obtained in Step 1 in N,N-dimethylformamide (3 ml) was added 3-cyanobenzylbromide (0.19 g), and the mixture was stirred at 105° C. for 5 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (85 mg).

Provenance & Evidence