4-(Methylsulfonyl)benzyl Bromide → HCID 68661659, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino-5-chloronicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 1-(bromomethyl)-4-(methylsulfonyl)benzene (0.33 g), and the mixture was stirred at 100° C. for 8 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (126 mg).

Provenance & Evidence