1-(Bromomethyl)-3-chlorobenzene → 1-(3-Chlorobenzyl)-2-imino-5-methyl-1,2-dihydropyridine-3-carboxamide hydrobromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino-5-methylnicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 3-chlorobenzylbromide (0.31 g), and the mixture was stirred at 100° C. for 6 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (0.15 g).

Provenance & Evidence