2-Amino-5-chloronicotinamide → HCID 68662148, compound

Participants

Reaction Conditions

Reaction Steps

(Step 3) To a solution of 2-amino-5-chloronicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 3-(bromomethyl)-5-chloro-N-methylbenzamide (0.28 g), and the mixture was stirred at 100° C. for 12 hr. The reaction mixture was diluted with ethyl acetate. The solvent was removed, and the obtained precipitate was dissolved in methanol and crystallized from ethyl acetate. The obtained crystals were recrystallized from methanol-ethyl acetate to give the title compound (0.11 g).

Provenance & Evidence