Triethylamine → HCID 68662189, compound

Participants

Reaction Steps

To a solution of 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide (0.5 g) in ethanol (5 ml) was added a solution (3 ml) of 3-methoxybenzylamine (410 μl) and triethylamine (450 μl) in ethanol at 0° C., and the mixture was stirred at room temperature for 24 hr. The reaction solvent was evaporated under reduced pressure, and the residue was purified by preparative HPLC. 4N Hydrochloric acid-ethyl acetate solution (1 ml) was added to the obtained yellow oil at room temperature, and the precipitated crystals were filtered and recrystallized to give the title compound (110 mg).

Provenance & Evidence