HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamide → 5-chloro-1-[(2R)-3,4-dihydro-2H-chromen-2-ylmethyl]-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamide | HCID 541792 | — |
| Reactant | (R)-chroman-2-ylmethanamine hydrochloride | HCID 55250747 | — |
| Product | 5-chloro-1-[(2R)-3,4-dihydro-2H-chromen-2-ylmethyl]-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride | HCID 68661486 | — |
Reaction Steps
According to the method of Example 160, 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide was reacted with 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]methanamine hydrochloride to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470859B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-60051e17d8ec48b0b1580a9ad44daf13 |
| Source note | uspto-grants-2013_06 |