1-(Bromomethyl)-3,5-difluoro-2-methoxybenzene → HCID 68661696, compound

HRID 1260882Notes

Reaction equation

HRID 1260882 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[C:15]=1[O:22][CH3:23]>>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[C:15]=2[O:22][CH3:23])[CH:9]=1

Participants

3

Reactant 2

HCID 177506901-(Bromomethyl)-3,5-difluoro-2-methoxybenzeneHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 68661696HCID 68661696, compound

Procedure

According to the method of Example 172, 2-amino-5-chloronicotinamide was reacted with 1-(bromomethyl)-3,5-difluoro-2-methoxybenzene to give the title compound.

Sources & evidence

ORD record
ord-a7bf976db7094ab7b5ecd5cad3195e54
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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